Potassium Carbonate → N-[6-(3-amino-4-chlorophenoxy)imidazo[1,2-b]pyridazin-2-yl]-2-methylcyclopropanecarboxamide

HRID 1667897

반응식

HRID 1667897 반응식
[NH2:1][C:2]1[CH:3]=[C:4]([OH:9])[CH:5]=[CH:6][C:7]=1[Cl:8].I[C:11]1[CH:12]=[CH:13][C:14]2[N:15]([CH:17]=[C:18]([NH:20][C:21]([CH:23]3[CH2:25][CH:24]3[CH3:26])=[O:22])[N:19]=2)[N:16]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[NH2:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][C:7]=1[Cl:8])[O:9][C:11]1[CH:12]=[CH:13][C:14]2[N:15]([CH:17]=[C:18]([NH:20][C:21]([CH:23]3[CH2:25][CH:24]3[CH3:26])=[O:22])[N:19]=2)[N:16]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 50700783-Amino-4-chlorophenolHCID 57505473N-(6-iodoimidazo[1,2-b]pyridazin-2-yl)-2-methylcyclopropanecarboxamide

생성물 1

HCID 57505474N-[6-(3-amino-4-chlorophenoxy)imidazo[1,2-b]pyridazin-2-yl]-2-methylcyclopropanecarboxamide수율 73.4%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Using 3-amino-4-chlorophenol (1.57 g, 11.0 mmol), N,N-dimethylformamide (25.0 mL), N-(6-iodoimidazo[1,2-b]pyridazin-2-yl)-2-methylcyclopropanecarboxamide (2.50 g, 7.31 mmol) and potassium carbonate (2.02 g, 14.6 mmol), and in the same manner as in Example 82, the title compound (1.92 g, 73%) was obtained as a brown powder.

출처 및 근거

ORD 기록
ord-501171ca79a84cc89ff70cdf86d01666
출처 데이터셋
uspto-grants-2011_10
특허 번호
US08044049B2

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