Dimethylformamide → 3-tert-butyl-N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-1-methyl-1H-pyrazole-5-carboxamide

HRID 1668035

반응식

HRID 1668035 반응식
[C:1]([C:5]1[CH:9]=[C:8]([C:10]([OH:12])=O)[N:7]([CH3:13])[N:6]=1)([CH3:4])([CH3:3])[CH3:2].CN(C)C=O.C(Cl)(=O)C(Cl)=O.[NH2:25][C:26]1[CH:27]=[C:28]([CH:45]=[CH:46][C:47]=1[CH3:48])[O:29][C:30]1[CH:31]=[CH:32][C:33]2[N:34]([CH:36]=[C:37]([NH:39][C:40]([CH:42]3[CH2:44][CH2:43]3)=[O:41])[N:38]=2)[N:35]=1>CN(C)C(=O)C.O1CCCC1>[C:1]([C:5]1[CH:9]=[C:8]([C:10]([NH:25][C:26]2[CH:27]=[C:28]([O:29][C:30]3[CH:31]=[CH:32][C:33]4[N:34]([CH:36]=[C:37]([NH:39][C:40]([CH:42]5[CH2:43][CH2:44]5)=[O:41])[N:38]=4)[N:35]=3)[CH:45]=[CH:46][C:47]=2[CH3:48])=[O:12])[N:7]([CH3:13])[N:6]=1)([CH3:2])([CH3:3])[CH3:4]

참가 물질

7

반응물 4

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 7205293-tert-butyl-1-methyl-1H-pyrazole-5-carboxylic acidHCID 57505476N-[6-(3-amino-4-methylphenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide

생성물 1

HCID 575055863-tert-butyl-N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-1-methyl-1H-pyrazole-5-carboxamide수율 41%

시약·촉매·용매 2

HCID 8028Tetrahydrofuran용매HCID 31374Dimethylacetamide용매

실험 절차

Using 3-tert-butyl-1-methyl-1H-pyrazole-5-carboxylic acid (61 mg, 0.33 mmol), tetrahydrofuran (1.8 mL), N,N-dimethylformamide (30 μL, 0.39 mmol), oxalyl chloride (44 μL, mmol), N-[6-(3-amino-4-methylphenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide (90 mg, 0.28 mmol) and N,N-dimethylacetamide (1.8 mL), and in the same manner as in Example 119, the title compound (55 mg, 41%) was obtained as a white powder.

출처 및 근거

ORD 기록
ord-46b219ee2a6d42dc9a82b1bf0faca064
출처 데이터셋
uspto-grants-2011_10
특허 번호
US08044049B2

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