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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Water → (-)-(cis)-N-(7-bromo-8,12-difluoro-1,3,4,14b-tetrahydro-2H-dibenzo[b,f]pyrido[1,2-d][1,4]oxazepin-1-yl)-2,2,2-trifluoroacetamide

HRID 1668359
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HRID 1668359 반응식
[Br:1][C:2]1[C:22]([F:23])=[CH:21][C:5]2[O:6][C:7]3[CH:19]=[C:18]([F:20])[CH:17]=[CH:16][C:8]=3[C@H:9]3[C@H:14]([NH2:15])[CH2:13][CH2:12][CH2:11][N:10]3[C:4]=2[CH:3]=1.C(N(CC)CC)C.[F:31][C:32]([F:39])([F:38])[C:33](OCC)=[O:34].O>CO>[Br:1][C:2]1[C:22]([F:23])=[CH:21][C:5]2[O:6][C:7]3[CH:19]=[C:18]([F:20])[CH:17]=[CH:16][C:8]=3[C@H:9]3[C@H:14]([NH:15][C:33](=[O:34])[C:32]([F:39])([F:38])[F:31])[CH2:13][CH2:12][CH2:11][N:10]3[C:4]=2[CH:3]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 962WaterHCID 8471TriethylamineHCID 9794Ethyl trifluoroacetateHCID 67359100(-)-(cis)-7-bromo-8,12-difluoro-1,3,4,14b-tetrahydro-2H-dibenzo[b,f]pyrido[1,2-d][1,4]oxazepine-1-amine

생성물 1

HCID 86619616(-)-(cis)-N-(7-bromo-8,12-difluoro-1,3,4,14b-tetrahydro-2H-dibenzo[b,f]pyrido[1,2-d][1,4]oxazepin-1-yl)-2,2,2-trifluoroacetamide수율 94.3%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of (−)-(cis)-7-bromo-8,12-difluoro-1,3,4,14b-tetrahydro-2H-dibenzo[b,f]pyrido[1,2-d][1,4]oxazepine-1-amine (2.32 g, 6.09 mmol) in a mixture of methanol (80 mL) and triethylamine (5.1 mL, 36.3 mmol), ethyl trifluoroacetate (4.3 mL, 36.3 mmol) was added and the resulting mixture was stirred at ambient temperature for 2 h. Water (120 mL) was added and stirred for additional 10 min. The formed precipitate was filtered off to yield the title compound (2.74 g, 94%).

후처리

  1. additionwas added
  2. stirringstirred for additional 10 min
  3. filtrationThe formed precipitate was filtered off

출처 및 근거

ORD 기록
ord-db8b649633ce45aba0c41e22f5e93c4c
출처 데이터셋
uspto-grants-2011_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07989442B2

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