1,1-dimethylethyl 10-bromo-2-methyl-6,7,8,9-tetrahydro-5H-[1,3]oxazolo[4,5-h][3]benzazepine-7-carboxylate → HCID 59150520, 화합물

HRID 1668587노트

반응식

HRID 1668587 반응식
[Br:1][C:2]1[C:12]2[CH2:11][CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8][CH2:7][C:6]=2[CH:5]=[C:4]2[N:20]=[C:21]([CH3:23])[O:22][C:3]=12>C(Cl)Cl>[Br:1][C:2]1[C:12]2[CH2:11][CH2:10][NH:9][CH2:8][CH2:7][C:6]=2[CH:5]=[C:4]2[N:20]=[C:21]([CH3:23])[O:22][C:3]=12

참가 물질

3

반응물 1

HCID 591504831,1-dimethylethyl 10-bromo-2-methyl-6,7,8,9-tetrahydro-5H-[1,3]oxazolo[4,5-h][3]benzazepine-7-carboxylate

생성물 1

HCID 59150520HCID 59150520, 화합물수율 99.3%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To a stirred solution of 1,1-dimethylethyl 10-bromo-2-methyl-6,7,8,9-tetrahydro-5H-[1,3]oxazolo[4,5-h][3]benzazepine-7-carboxylate (71 mg) in DCM (2.1 ml) TFA (0.9 ml) was added dropwise. After 30 min. the mixture was diluted with DCM and washed with 5% K2CO3. The organic phase was dried (Na2SO4) and concentrated to afford the title compound (52 mg).

후처리

  1. washwashed with 5% K2CO3
  2. dry with materialThe organic phase was dried (Na2SO4)
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-e5cb115952d54dee87f8de6278c8ea9d
출처 데이터셋
uspto-grants-2011_08
특허 번호
US07989444B2

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