5-(5-[(3-chloropropyl)thio]-4-methyl-4H-1,2,4-triazol-3-yl)-2-methylquinoline → 2-ethyl-7-(3-{[4-methyl-5-(2-methyl-5-quinolinyl)-4H-1,2,4-triazol-3-yl]thio}propyl)-4,7,8,9-tetrahydro-5H-[1,3]thiazolo[4,5-h][3]benzazepine hydrochloride
반응식
[CH2:1]([C:3]1[S:4][C:5]2[C:15]([N:16]=1)=[CH:14][C:8]1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13][C:7]=1[CH:6]=2)[CH3:2].[Cl:17][CH2:18][CH2:19][CH2:20][S:21][C:22]1[N:23]([CH3:38])[C:24]([C:27]2[CH:36]=[CH:35][CH:34]=[C:33]3[C:28]=2[CH:29]=[CH:30][C:31]([CH3:37])=[N:32]3)=[N:25][N:26]=1>>[ClH:17].[CH2:1]([CH:3]1[N:16]=[C:15]2[C:5](=[CH:6][C:7]3[CH2:13][CH2:12][N:11]([CH2:18][CH2:19][CH2:20][S:21][C:22]4[N:23]([CH3:38])[C:24]([C:27]5[CH:36]=[CH:35][CH:34]=[C:33]6[C:28]=5[CH:29]=[CH:30][C:31]([CH3:37])=[N:32]6)=[N:25][N:26]=4)[CH2:10][CH2:9][C:8]=3[CH2:14]2)[S:4]1)[CH3:2]참가 물질
3
반응물 2
생성물 1
실험 절차
The title compound was prepared in analogy to General Procedure 1 from: 2-ethyl-6,7,8,9-tetrahydro-5H-[1,3]thiazolo[4,5-h][3]benzazepine (0.43 mmol) and 5-{5-[(3-chloropropyl)thio]-4-methyl-4H-1,2,4-triazol-3-yl}-2-methylquinoline (0.52 mmol) and was obtained as a colourless slightly hygroscopic solid (60 mg).