HCID 59150509, 화합물 → 10-bromo-7-(4-{[4-methyl-5-(2-methyl-5-quinolinyl)-4H-1,2,4-triazol-3-yl]thio}butyl)-2-(trifluoromethyl)-6,7,8,9-tetrahydro-5H-[1,3]oxazolo[4,5-h][3]benzazepine hydrochloride

HRID 1668635노트

반응식

HRID 1668635 반응식
[Br:1][C:2]1[C:12]2[CH2:11][CH2:10][NH:9][CH2:8][CH2:7][C:6]=2[CH:5]=[C:4]2[N:13]=[C:14]([C:16]([F:19])([F:18])[F:17])[O:15][C:3]=12.[Cl:20][CH2:21][CH2:22][CH2:23][CH2:24][S:25][C:26]1[N:27]([CH3:42])[C:28]([C:31]2[CH:40]=[CH:39][CH:38]=[C:37]3[C:32]=2[CH:33]=[CH:34][C:35]([CH3:41])=[N:36]3)=[N:29][N:30]=1>>[ClH:20].[Br:1][C:2]1[C:12]2[CH2:11][CH2:10][N:9]([CH2:21][CH2:22][CH2:23][CH2:24][S:25][C:26]3[N:27]([CH3:42])[C:28]([C:31]4[CH:40]=[CH:39][CH:38]=[C:37]5[C:32]=4[CH:33]=[CH:34][C:35]([CH3:41])=[N:36]5)=[N:29][N:30]=3)[CH2:8][CH2:7][C:6]=2[CH:5]=[C:4]2[N:13]=[C:14]([C:16]([F:19])([F:17])[F:18])[O:15][C:3]=12

참가 물질

3

반응물 2

HCID 59150509HCID 59150509, 화합물HCID 5915052210-bromo-2-(trifluoromethyl)-6,7,8,9-tetrahydro-5H-[1,3]oxazolo[4,5-h][3]benzazepine

생성물 1

HCID 6735946710-bromo-7-(4-{[4-methyl-5-(2-methyl-5-quinolinyl)-4H-1,2,4-triazol-3-yl]thio}butyl)-2-(trifluoromethyl)-6,7,8,9-tetrahydro-5H-[1,3]oxazolo[4,5-h][3]benzazepine hydrochloride

실험 절차

The title compound was prepared in analogy to General Procedure 1 from 10-Bromo-2-(trifluoromethyl)-6,7,8,9-tetrahydro-5H-[1,3]oxazolo[4,5-h][3]benzazepine (120 mg) and 5-{5-[(4-chlorobutyl)thio]-4-methyl-4H-1,2,4-triazol-3-yl}-2-methylquinoline (177 mg) and was obtained as a colourless slightly hygroscopic solid (66 mg).

출처 및 근거

ORD 기록
ord-def857f901e647048aaf40cb602a943b
출처 데이터셋
uspto-grants-2011_08
특허 번호
US07989444B2

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