Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → HCID 67341951, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | tert-Butyl (3S)-3-(aminomethyl)pyrrolidine-1-carboxylate | HCID 1514454 | — |
| 반응물 | n-(2,6-Dichlorobenzyl)-6-chloro-3-nitropyridin-2-amine | HCID 59705189 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | HCID 67341951 | HCID 67341951 | 27.3% |
반응 단계
A mixture of 16 (100 mg, 0.34 mmol), (S)-tert-Butyl-3-(aminomethyl)pyrrolidine-1-carboxylate (0.4 g, 2.0 mmol), potassium carbonate (56.4 mg, 0.41 mmol) in 10 mL MeCN was stirred at reflux for 2 hours. The solvent was removed by vacuum and the residue was purified by silica gel chromatography (MeOH:DCM=1:10) giving 17 [46 mg, 27% yield].
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07989459B2 |
| 출처 데이터셋 | uspto-grants-2011_08 |
| ORD ID | ord-162a6e66d05144caa87ad93662f9af14 |
| 출처 메모 | uspto-grants-2011_08 |