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Isopropanol → N-(2,3-dihydro-1H-inden-5-yl)-8-iodo-7-methylquinazolin-4-amine hydrochloride

HRID 1668924
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HRID 1668924 반응식
[CH2:1]1[C:9]2[C:4](=[CH:5][C:6]([NH2:10])=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.[Cl:11][C:12]1[C:21]2[C:16](=[C:17]([I:23])[C:18]([CH3:22])=[CH:19][CH:20]=2)[N:15]=[CH:14][N:13]=1.CC(O)C>CCOC(C)=O>[ClH:11].[CH2:1]1[C:9]2[C:4](=[CH:5][C:6]([NH:10][C:12]3[C:21]4[C:16](=[C:17]([I:23])[C:18]([CH3:22])=[CH:19][CH:20]=4)[N:15]=[CH:14][N:13]=3)=[CH:7][CH:8]=2)[CH2:3][CH2:2]1
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참가 물질

5

반응물 3

HCID 3776IsopropanolHCID 90496Indan-5-amineHCID 584664844-Chloro-8-iodo-7-methylquinazoline

생성물 1

HCID 67338686N-(2,3-dihydro-1H-inden-5-yl)-8-iodo-7-methylquinazolin-4-amine hydrochloride수율 87%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

반응 조건

온도
110 °C

실험 절차

2,3-Dihydro-1H-inden-5-amine (109 mg, 821 μmol), 4-chloro-8-iodo-7-methylquinazoline (250 mg, 821 μmol) and IPA (5 mL) were added to microwave-vial. The reaction mixture was heated at 110° C. for 10 min. A precipitate formed upon cooling. The crude product was diluted with EtOAc (20 mL), filtered, washed twice with EtOAc (20 mL) and air-dried to give N-(2,3-dihydro-1H-inden-5-yl)-8-iodo-7-methylquinazolin-4-amine hydrochloride (311 mg, 87%) as an amorphous off-white solid. MS (M+H)+ 402.

후처리

  1. customA precipitate formed
  2. temperatureupon cooling
  3. filtrationfiltered
  4. washwashed twice with EtOAc (20 mL)
  5. customair-dried

출처 및 근거

ORD 기록
ord-8f110ed7139f4f41b4cef882103f96be
출처 데이터셋
uspto-grants-2011_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07989461B2

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