Lawesson's reagent → HCID 58829668, 화합물

HRID 1668936노트

반응식

HRID 1668936 반응식
COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:10])=CC=1.[F:23][C:24]1[C:42]([C:43]2[CH:44]=[C:45]3[C:50](=[CH:51][CH:52]=2)[N:49]=[C:48]([NH:53][CH3:54])[N:47]=[CH:46]3)=[C:41]([CH3:55])[CH:40]=[CH:39][C:25]=1[C:26]([NH:28][C:29]1[CH:34]=[CH:33][CH:32]=[C:31]([O:35][CH:36]([CH3:38])[CH3:37])[CH:30]=1)=O>C1(C)C=CC=CC=1>[F:23][C:24]1[C:42]([C:43]2[CH:44]=[C:45]3[C:50](=[CH:51][CH:52]=2)[N:49]=[C:48]([NH:53][CH3:54])[N:47]=[CH:46]3)=[C:41]([CH3:55])[CH:40]=[CH:39][C:25]=1[C:26](=[S:10])[NH:28][C:29]1[CH:34]=[CH:33][CH:32]=[C:31]([O:35][CH:36]([CH3:38])[CH3:37])[CH:30]=1

참가 물질

4

반응물 2

HCID 87949Lawesson's reagentHCID 588290582-fluoro-N-(3-isopropoxyphenyl)-4-methyl-3-(2-(methylamino)quinazolin-6-yl)benzamide

생성물 1

HCID 58829668HCID 58829668, 화합물

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A mixture of Lawesson's reagent (47 mg, 115 μmol) and 2-fluoro-N-(3-isopropoxyphenyl)-4-methyl-3-(2-(methylamino)quinazolin-6-yl)benzamide (93 mg, 209 μmol) in toluene (8 mL) was heated at reflux for 16 h. Solvent was removed in vacuo and the residue was purified by flash chromatography (25-70% EtOAc/hexane) to give the title compound. MS (M+H)+ 461.

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 16 h
  3. customSolvent was removed in vacuo
  4. customthe residue was purified by flash chromatography (25-70% EtOAc/hexane)

출처 및 근거

ORD 기록
ord-f1a9115169444a1ea6ea1559d74dba30
출처 데이터셋
uspto-grants-2011_08
특허 번호
US07989461B2

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