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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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tert-butyl {2-[[(7R)-14-cyclohexyl-11-[({[(2,2-dimethoxyethyl)(methyl)amino]-sulfonyl}amino)carbonyl]-3-(pyridin-2-ylmethoxy)-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocin-7-yl](methyl)amino]ethyl}methylcarbamate → (7R)-14-cyclohexyl-7-{methyl[2-(methylamino)ethyl]amino}-N-{[methyl(2-oxoethyl)amino]sulfonyl}-3-(pyridin-2-ylmethoxy)-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxamide

HRID 1669421
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HRID 1669421 반응식
[CH:1]1([C:7]2[C:8]3[CH:9]=[CH:10][C:11]([C:47]([NH:49][S:50]([N:53]([CH2:55][CH:56](OC)[O:57]C)[CH3:54])(=[O:52])=[O:51])=[O:48])=[CH:12][C:13]=3[N:14]3[C:21]=2[C:20]2[CH:22]=[CH:23][C:24]([O:26][CH2:27][C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][N:29]=4)=[CH:25][C:19]=2[O:18][CH2:17][C@H:16]([N:34]([CH3:46])[CH2:35][CH2:36][N:37](C)[C:38](=O)OC(C)(C)C)[CH2:15]3)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1>C(Cl)Cl.O.C(O)(C(F)(F)F)=O>[CH:1]1([C:7]2[C:8]3[CH:9]=[CH:10][C:11]([C:47]([NH:49][S:50]([N:53]([CH3:54])[CH2:55][CH:56]=[O:57])(=[O:51])=[O:52])=[O:48])=[CH:12][C:13]=3[N:14]3[C:21]=2[C:20]2[CH:22]=[CH:23][C:24]([O:26][CH2:27][C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][N:29]=4)=[CH:25][C:19]=2[O:18][CH2:17][C@H:16]([N:34]([CH3:46])[CH2:35][CH2:36][NH:37][CH3:38])[CH2:15]3)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

3

반응물 1

HCID 67344800tert-butyl {2-[[(7R)-14-cyclohexyl-11-[({[(2,2-dimethoxyethyl)(methyl)amino]-sulfonyl}amino)carbonyl]-3-(pyridin-2-ylmethoxy)-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocin-7-yl](methyl)amino]ethyl}methylcarbamate

생성물 1

HCID 86627898(7R)-14-cyclohexyl-7-{methyl[2-(methylamino)ethyl]amino}-N-{[methyl(2-oxoethyl)amino]sulfonyl}-3-(pyridin-2-ylmethoxy)-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxamide

시약·촉매·용매 1

HCID 18672661TFA dichloromethane water
용매

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온도
40 °C

실험 절차

tert-butyl {2-[[(7R)-14-cyclohexyl-11-[({[(2,2-dimethoxyethyl)(methyl)amino]-sulfonyl}amino)carbonyl]-3-(pyridin-2-ylmethoxy)-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocin-7-yl](methyl)amino]ethyl}methylcarbamate was dissolved in DCM/H2O/TFA (8:1:3, 15 mM). The mixture was warmed to 40° C. After 30 min all volatiles were evaporated in vacuo and the residual material was coevaporated twice with toluene. The remaining yellow oil was used in the next reaction without further purification.

후처리

  1. customAfter 30 min all volatiles were evaporated in vacuo
  2. customThe remaining yellow oil was used in the next reaction without further purification

출처 및 근거

ORD 기록
ord-8d02a564d8da4eaa873019bd7fc119fe
출처 데이터셋
uspto-grants-2011_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07989438B2

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