Imidazole → HCID 67346559, 화합물

HRID 1669428노트

반응식

HRID 1669428 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][C:3]=1[CH2:10][OH:11].N1C=CN=C1.[CH:17]([Si:20](Cl)([CH:24]([CH3:26])[CH3:25])[CH:21]([CH3:23])[CH3:22])([CH3:19])[CH3:18]>CN(C=O)C>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][C:3]=1[CH2:10][O:11][Si:20]([CH:24]([CH3:26])[CH3:25])([CH:21]([CH3:23])[CH3:22])[CH:17]([CH3:19])[CH3:18]

참가 물질

5

반응물 3

HCID 795ImidazoleHCID 139400Triisopropylsilyl chlorideHCID 10867706(2-Bromo-5-methoxyphenyl)methanol

생성물 1

HCID 67346559HCID 67346559, 화합물수율 94%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

(2-Bromo-5-methoxyphenyl)methanol (1 eq) was dissolved in anhydrous DMF (1.1M solution) and imidazole (1.05 eq) was added. To the stirred solution triisopropylsilyl chloride (1.1 eq) was added and the resulting mixture was stirred at RT for 8 h. All volatiles were evaporated in vacuo and the residual material was filtered with PE/EtOAc (9:1) over a pad of silica gel. After evaporation in vacuo the product was obtained as a colourless oil (94%), which was used without further characterization in the next reaction.

후처리

  1. customAll volatiles were evaporated in vacuo
  2. filtrationthe residual material was filtered with PE/EtOAc (9:1) over a pad of silica gel
  3. customAfter evaporation in vacuo the product

출처 및 근거

ORD 기록
ord-a0c41e985ad54374be12de9a9bfa83de
출처 데이터셋
uspto-grants-2011_08
특허 번호
US07989438B2

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