N-(6-acetyl-2-chloro-3-methoxyphenyl)-4-isopropylthiazole-2-carboxamide → HCID 178487693, 화합물

HRID 1669566노트

반응식

HRID 1669566 반응식
[CH:1]([C:4]1[N:5]=[C:6]([C:9]([NH:11][C:12]2[C:17]([Cl:18])=[C:16]([O:19][CH3:20])[CH:15]=[CH:14][C:13]=2[C:21](=[O:23])[CH3:22])=O)[S:7][CH:8]=1)([CH3:3])[CH3:2].OC1C2C(=C(C)C(OC)=CC=2)N=C(C2SC=CN=2)C=1>>[Cl:18][C:17]1[C:16]([O:19][CH3:20])=[CH:15][CH:14]=[C:13]2[C:12]=1[N:11]=[C:9]([C:6]1[S:7][CH:8]=[C:4]([CH:1]([CH3:3])[CH3:2])[N:5]=1)[CH:22]=[C:21]2[OH:23]

참가 물질

3

반응물 2

HCID 56605150N-(6-acetyl-2-chloro-3-methoxyphenyl)-4-isopropylthiazole-2-carboxamideHCID 178487701HCID 178487701, 화합물

생성물 1

HCID 178487693HCID 178487693, 화합물

실험 절차

The title product 46 was prepared (58%) from 2′-[[(4-isopropylthiazole-2-yl)(oxo)-methyl]amino]-3′-chloro-4′-methoxyacetophenone (45) following the procedure reported for 4-hydroxy-7-methoxy-8-methyl-2-(thiazol-2-yl)quinoline (24): m/z=335 (M+H)+.

출처 및 근거

ORD 기록
ord-a8c6e2cd00bf40ddabb9d07193184e0a
출처 데이터셋
uspto-grants-2011_08
특허 번호
US07989471B2

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