5-Aminovaleric acid → Methyl 5-aminopentanoate hydrochloride

HRID 16696

반응식

HRID 16696 반응식
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6]([OH:8])=[O:7].S(Cl)([Cl:11])=O.[CH3:13]O>>[ClH:11].[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6]([O:8][CH3:13])=[O:7]

참가 물질

4

반응물 3

HCID 1385-Aminovaleric acidHCID 887MethanolHCID 24386Thionyl Chloride

생성물 1

HCID 13672034Methyl 5-aminopentanoate hydrochloride

실험 절차

5-Aminovaleric acid (7.35 g) is dissolved in methanol (50 ml), and thereto is added dropwise thionyl chloride (4.9 ml) under ice-cooling. The reaction solution is then warmed to room temperature and stirred for 17 hours. The reaction solution is concentrated under reduced pressure. The resulting residue is suspended in diethyl ether and the precipitates are collected by filtration to give methyl 5-aminovalerate hydrochloride (9.93 g).

후처리

  1. temperaturecooling
  2. concentrationThe reaction solution is concentrated under reduced pressure
  3. filtrationthe precipitates are collected by filtration

출처 및 근거

ORD 기록
ord-aa88e5f4b1ca45bfa1e9bb7a8dcca652
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737161B2

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