Cyclobutyl 3-aminocrotonate → Cyclobutyl 5-acetyl-2,6-dimethyl-4-(5-fluoro-2-methyl-4-oxo-4H-chromen-8-yl)-1,4-dihydro-pyridine-3-carboxylate
반응식
[F:1][C:2]1[CH:11]=[CH:10][C:9]([CH:12]=[C:13]([C:17](=O)[CH3:18])[C:14](=[O:16])[CH3:15])=[C:8]2[C:3]=1[C:4](=[O:21])[CH:5]=[C:6]([CH3:20])[O:7]2.[NH2:22]/[C:23](/[CH3:32])=[CH:24]\[C:25]([O:27][CH:28]1[CH2:31][CH2:30][CH2:29]1)=[O:26]>CC(O)C>[C:14]([C:13]1[CH:12]([C:9]2[CH:10]=[CH:11][C:2]([F:1])=[C:3]3[C:8]=2[O:7][C:6]([CH3:20])=[CH:5][C:4]3=[O:21])[C:24]([C:25]([O:27][CH:28]2[CH2:31][CH2:30][CH2:29]2)=[O:26])=[C:23]([CH3:32])[NH:22][C:17]=1[CH3:18])(=[O:16])[CH3:15]참가 물질
4
실험 절차
150 mg (0.52 mmol) of 3-[(5-fluoro-2-methyl-4-oxo-4H-chromen-8-yl)methylene]pentane-2,4-dione are dissolved with 40.4 mg (0.26 mmol) of cyclobutyl 3-aminocrotonate in 5 ml of 2-propanol and heated under reflux under argon for 3 h. The solvent is removed in vacuo, and the residue is purified by column chromatography (mobile phase: ethyl acetate/cyclohexane 2:1). 54.8 mg (50% of theory) of the title compound are obtained as a yellow solid.