4-Amino-2,2,6,6-tetramethylpiperidine → 4-(5-amino-2-methylphenyl)-8-(2,6-difluorophenyl)-2-[(2,2,6,6-tetramethyl-4-piperidinyl)amino]pyrido[2,3-d]pyrimidin-7(8H)-one

반응식

[CH3:32][C:33]1([CH3:42])[NH:34][C:35]([CH3:40])([CH3:41])[CH2:36][CH:37]([NH2:39])[CH2:38]1.[NH2:1][c:2]1[cH:3][cH:4][c:5]([CH3:31])[c:6](-[c:8]2[c:9]3[c:10]([n:11][c:12]([S:14]([CH3:15])(=[O:16])=[O:17])[n:13]2)[n:18](-[c:23]2[c:24]([F:30])[cH:25][cH:26][cH:27][c:28]2[F:29])[c:19](=[O:22])[cH:20][cH:21]3)[cH:7]1>>[NH2:1][c:2]1[cH:3][cH:4][c:5]([CH3:31])[c:6](-[c:8]2[c:9]3[c:10]([n:11][c:12]([NH:39][CH:37]4[CH2:36][C:35]([CH3:40])([CH3:41])[NH:34][C:33]([CH3:32])([CH3:42])[CH2:38]4)[n:13]2)[n:18](-[c:23]2[c:24]([F:30])[cH:25][cH:26][cH:27][c:28]2[F:29])[c:19](=[O:22])[cH:20][cH:21]3)[cH:7]1

참가 물질

반응물 2

HCID 375244-Amino-2,2,6,6-tetramethylpiperidine

HCID 592126804-(5-amino-2-methylphenyl)-8-(2,6-difluorophenyl)-2-(methylsulfonyl)pyrido[2,3-d]pyrimidin-7(8H)-one

생성물 1

HCID 445292194-(5-amino-2-methylphenyl)-8-(2,6-difluorophenyl)-2-[(2,2,6,6-tetramethyl-4-piperidinyl)amino]pyrido[2,3-d]pyrimidin-7(8H)-one

출처 및 근거

ORD 기록: ord-98455309bfdd4cec9c935e394113fbce
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (9/10)
DOI: 10.1039/C8SC04228D

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