Acetonitrile → N-(4-(2-aminopyridin-4-yloxy)-2-fluorophenyl)pivalamide

HRID 1670300노트

반응식

HRID 1670300 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:15]=[CH:16][C:17]=1[NH:18][C:19](=[O:24])[C:20]([CH3:23])([CH3:22])[CH3:21])[O:5][C:6]1[CH:11]=[CH:10][N:9]=[C:8](C(N)=O)[CH:7]=1.C(#[N:27])C>>[NH2:27][C:8]1[CH:7]=[C:6]([O:5][C:4]2[CH:15]=[CH:16][C:17]([NH:18][C:19](=[O:24])[C:20]([CH3:23])([CH3:22])[CH3:21])=[C:2]([F:1])[CH:3]=2)[CH:11]=[CH:10][N:9]=1

참가 물질

3

반응물 2

HCID 6342AcetonitrileHCID 598530604-(3-Fluoro-4-pivalamidophenoxy)picolinamide

생성물 1

HCID 59852964N-(4-(2-aminopyridin-4-yloxy)-2-fluorophenyl)pivalamide수율 70%

실험 절차

Prepared in a manner similar to that which is described in Step A of Example 91. 4-(3-Fluoro-4-pivalamidophenoxy)picolinamide (110 mg, 0.33 mmol) in acetonitrile (4 mL) was converted to N-(4-(2-aminopyridin-4-yloxy)-2-fluorophenyl)pivalamide (70 mg, 70% yield). MS (ESI+): m/z 304.21 (M+H)+.

후처리

  1. customPrepared in a manner similar to that which

출처 및 근거

ORD 기록
ord-bb157ce6227f4fd3b13263ed3e299953
출처 데이터셋
uspto-grants-2011_08
특허 번호
US07989477B2

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