Benzyl Bromide → Benzyl 2-(3-(benzyloxy)phenyl)acetate

HRID 1670339노트

반응식

HRID 1670339 반응식
[OH:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([OH:11])=[O:10])[CH:5]=[CH:6][CH:7]=1.C([O-])([O-])=O.[K+].[K+].[CH2:18](Br)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>CN(C=O)C>[CH2:18]([O:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([O:11][CH2:8][C:4]2[CH:5]=[CH:6][CH:7]=[CH:2][CH:3]=2)=[O:10])[CH:5]=[CH:6][CH:7]=1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

참가 물질

5

반응물 3

HCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 121223'-Hydroxyphenylacetic acid

생성물 1

HCID 15470856Benzyl 2-(3-(benzyloxy)phenyl)acetate

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of 3-hydroxyphenylacetic acid (Acros, 3.04 g, 20 mmol) in 20 mL of DMF were added K2CO3 (6.90 g, 50 mmol) and benzyl bromide (4.75 mL, 40 mmol) at room temperature. The reaction mixture was stirred for 24 h. The suspension was filtered and washed with diethyl ether. The filtrate was then washed with brine and dried over MgSO4. Filtration, followed by concentration, provided the crude benzyl 2-(3-(benzyloxy)phenyl)acetate which was used in the next step. MS (ESI+) m/z 355 (M+Na)+.

후처리

  1. filtrationThe suspension was filtered
  2. washwashed with diethyl ether
  3. washThe filtrate was then washed with brine
  4. dry with materialdried over MgSO4
  5. filtrationFiltration
  6. concentrationfollowed by concentration

출처 및 근거

ORD 기록
ord-c11fc04207484e4e9fc6b7868895690d
출처 데이터셋
uspto-grants-2011_08
특허 번호
US07989477B2

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