Hydrogen chloride-ethyl acetate → 1-(2-Thienyl)piperazine hydrochloride

HRID 1670744

반응식

HRID 1670744 반응식
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[S:15][CH:16]=[CH:17][CH:18]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:19].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:19].[S:15]1[CH:16]=[CH:17][CH:18]=[C:14]1[N:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

참가 물질

4

반응물 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 673439001-Boc-4-(2-thienyl)piperazine

생성물 1

HCID 231498111-(2-Thienyl)piperazine hydrochloride수율 98%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

4-(2-Thienyl)piperazine-1-carboxylic acid tert-butyl ester (700 mg) was dissolved in ethyl acetate (4 ml), a 4N hydrochloric acid-ethyl acetate solution (4 ml) was added, and the mixture was stirred at room temperature for 1.5 hr. The precipitated solid was collected by filtration, washed with ethyl acetate and dried to give 1-(2-thienyl)piperazine hydrochloride (532 mg, yield 98%).

후처리

  1. filtrationThe precipitated solid was collected by filtration
  2. washwashed with ethyl acetate
  3. customdried

출처 및 근거

ORD 기록
ord-277e2fd057094455b0f702445eeefb32
출처 데이터셋
uspto-grants-2011_08
특허 번호
US07994196B2

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