참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | 2,4-Difluoro-5-iodobenzoic acid | HCID 11129795 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 2,4-Difluoro-5-iodobenzoyl chloride | HCID 57733987 | — |
반응 단계
To a solution of 11 (74.0 g, 260 mmol) in toluene (370 mL) was added thionyl chloride (95 mL, 1300 mmol) in DMF (2.5 mL, 26 mmol) and the mixture was heated to reflux for 4 h. The mixture was cooled to approximately 60° C. and filtered to remove insoluble material. The filtrate was concentrated under reduced pressure and residual thionyl chloride was co-evaporated with toluene (2×120 mL) to give crude 12 which was used without purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07994194B2 |
|---|
| 출처 데이터셋 | uspto-grants-2011_08 |
|---|
| ORD ID | ord-c4d12b2e96734e9aa9427c510d143ef6 |
|---|
| 출처 메모 | uspto-grants-2011_08 |
|---|
