Ammonium Chloride → 1-(2-Methoxy-4-methyl-phenyl)-propan-1-ol
반응식
[CH3:1][O:2][C:3]1[CH:10]=[C:9]([CH3:11])[CH:8]=[CH:7][C:4]=1[CH:5]=[O:6].[CH3:12][CH2:13][Mg+].[Br-].[Cl-].[NH4+]>C(OCC)C>[CH3:1][O:2][C:3]1[CH:10]=[C:9]([CH3:11])[CH:8]=[CH:7][C:4]=1[CH:5]([OH:6])[CH2:12][CH3:13]참가 물질
5
실험 절차
To a stirring solution of 2-methoxy-4-methylbenzaldehyde (1 g, 6.66 mmol) in diethyl ether (35 ml) at 0° C. is added EtMgBr (2.220 ml, 6.66 mmol). The mixture is stirred for 2 hours and then added to sat ammonium chloride solution. The mixture is extracted with ethyl acetate and the combined organic portions are washed with NaHCO3, water and brine dried (MgSO4) and reducing under vacuum to yield the title product as a clear oil. 1H NMR (400 MHz, CDCl3) δ 7.18 (d, 1H), 6.78 (d, 1H), 6.72 (s, 1H), 4.77 (t, 1H), 3.85 (s, 3H), 2.37 (s, 3H), 1.83 (m, 2H), 0.96 (t, 3H).
후처리
- additionadded
- extractionThe mixture is extracted with ethyl acetate
- washthe combined organic portions are washed with NaHCO3, water and brine
- dry with materialdried (MgSO4)
출처 및 근거
- ORD 기록
- ord-0978c5cdbfdb4018beb525bac7e36a37
- 출처 데이터셋
- uspto-grants-2011_08
- 특허 번호
- US07994203B2
반응 노트
불러오는 중…