5-Fluororesorcinol → Umbelliferone

HRID 1671494노트

반응식

HRID 1671494 반응식
F[C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[C:4]([OH:9])[CH:3]=1>S(=O)(=O)(O)O>[OH:9][C:4]1[CH:5]=[C:6]2[C:7]([CH:4]=[CH:5][C:6](=[O:8])[O:8]2)=[CH:2][CH:3]=1

참가 물질

3

반응물 1

HCID 126587785-Fluororesorcinol

생성물 1

HCID 5281426Umbelliferone수율 146.9%

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매

실험 절차

1-Fluoro-3,5-dihydroxybenzene (1.0 g, 7.8 mmol) and ethyl 2-benzyl acetoacetate (1.72 g, 7.8 mmol) are suspended in 20 mL of 70% sulfuric acid at room temperature. The reaction mixture is stirred for 24 hours and poured into ice water. The solid is filtered and washed with water. The yellowish crude product is re-crystallized from hot ethanol to afford the 7-hydroxy coumarin intermediate (929 mg, 42%).

후처리

  1. filtrationThe solid is filtered
  2. washwashed with water
  3. customThe yellowish crude product is re-crystallized from hot ethanol

출처 및 근거

ORD 기록
ord-b699d2efe0e04786b171c1278f5726a9
출처 데이터셋
uspto-grants-2011_08
특허 번호
US07994318B2

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