Cyclopropanecarbonyl chloride → Cyclopropanecarboxylic acid[2-((r)-indan-1-ylamino)-quinolin-5-yl]-amide

반응식

[C@H:1]1([NH:10][C:11]2[CH:20]=[CH:19][C:18]3[C:17]([NH2:21])=[CH:16][CH:15]=[CH:14][C:13]=3[N:12]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.[CH:22]1([C:25](Cl)=[O:26])[CH2:24][CH2:23]1>>[C@H:1]1([NH:10][C:11]2[CH:20]=[CH:19][C:18]3[C:13](=[CH:14][CH:15]=[CH:16][C:17]=3[NH:21][C:25]([CH:22]3[CH2:24][CH2:23]3)=[O:26])[N:12]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1

참가 물질

반응물 2

HCID 77637Cyclopropanecarbonyl chloride

HCID 44219082(R)-N2-Indan-1-yl-quinoline-2,5-diamine

생성물 1

HCID 44219238Cyclopropanecarboxylic acid[2-((r)-indan-1-ylamino)-quinolin-5-yl]-amide

실험 절차

The title compound, MS: m/e=344.3 (M+H+), was prepared in accordance with the general method of example 18 from (R)—N2-indan-1-yl-quinoline-2,5-diamine and cyclopropane carbonyl chloride.

출처 및 근거

ORD 기록: ord-f4acd3f5ade545d7b9825c772c75132d
출처 데이터셋: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07994324B2

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