Acetic Acid → Acetic Acid 2-oxo-3-phenyl-propyl Ester

HRID 1671647

반응식

HRID 1671647 반응식
[C:1]([OH:4])(=[O:3])[CH3:2].C(N(CC)CC)C.Cl[C:13]1[CH:14]=[C:15]([CH2:20][C:21](=[O:23])[CH3:22])[CH:16]=[CH:17][C:18]=1Cl>>[O:23]=[C:21]([CH2:20][C:15]1[CH:16]=[CH:17][CH:18]=[CH:13][CH:14]=1)[CH2:22][O:3][C:1](=[O:4])[CH3:2]

참가 물질

4

반응물 3

HCID 176Acetic AcidHCID 8471TriethylamineHCID 810603',4'-Dichloropropiophenone

생성물 1

HCID 12222463Acetic Acid 2-oxo-3-phenyl-propyl Ester수율 33%

실험 절차

This crude material was reacted with acetic acid (1.42 mL, 1.49 g, 24.8 mmol) and triethylamine (3.46 mL, 2.51 g, 24.8 mmol), as described above for the synthesis of 3-(3,4-dichlorophenyl)propan-2-one. Flash chromatography over silica gel (10-30% ethyl acetate in hexanes) gave pure product (0.83 g, 33% yield). 1H NMR (400 MHz, DMSO-D6) δ ppm 2.08 (s, 3H) 3.80 (s, 2H) 4.85 (s, 2H) 7.17-7.36 (m, 5H).

출처 및 근거

ORD 기록
ord-f0afcc82b042455eb9b0abebd8e921c9
출처 데이터셋
uspto-grants-2011_08
특허 번호
US07994333B2

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