Methanol → Methyl 2-fluoro-4-nitrobenzoate

HRID 1671660노트

반응식

HRID 1671660 반응식
S(=O)(=O)(O)O.[F:6][C:7]1[CH:15]=[C:14]([N+:16]([O-:18])=[O:17])[CH:13]=[CH:12][C:8]=1[C:9]([OH:11])=[O:10].[CH3:19]O>>[F:6][C:7]1[CH:15]=[C:14]([N+:16]([O-:18])=[O:17])[CH:13]=[CH:12][C:8]=1[C:9]([O:11][CH3:19])=[O:10]

참가 물질

4

반응물 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 3026792-Fluoro-4-nitrobenzoic acid

생성물 1

HCID 3013872Methyl 2-fluoro-4-nitrobenzoate

실험 절차

Concentrated sulfuric acid (5 ml) was added to a methanol (1300 ml) solution of 2-fluoro-4-nitrobenzoic acid (140 g), and heated under reflux for 48 hours. The solvent was evaporated away under reduced pressure, water was added to it, and the formed solid was taken out through filtration. After dried under reduced pressure, the entitled compound was obtained as a yellow solid.

후처리

  1. temperatureheated
  2. temperatureunder reflux for 48 hours
  3. customThe solvent was evaporated away under reduced pressure, water
  4. additionwas added to it
  5. filtrationthe formed solid was taken out through filtration
  6. customAfter dried under reduced pressure
  7. customthe entitled compound was obtained as a yellow solid

출처 및 근거

ORD 기록
ord-54c5adcb1a4140c1b230412f77f4fc8b
출처 데이터셋
uspto-grants-2011_08
특허 번호
US07994331B2

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