Nitric Acid → HCID 57433540, 화합물

HRID 1671663노트

반응식

HRID 1671663 반응식
[N+:1]([O-:4])(O)=[O:2].[F:5][C:6]1[CH:15]=[C:14]([NH:16][C:17]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=2)=[O:18])[CH:13]=[CH:12][C:7]=1[C:8]([O:10][CH3:11])=[O:9]>C(=O)([O-])[O-].[Na+].[Na+]>[F:5][C:6]1[CH:15]=[C:14]([NH:16][C:17]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=2)=[O:18])[C:13]([N+:1]([O-:4])=[O:2])=[CH:12][C:7]=1[C:8]([O:10][CH3:11])=[O:9]

참가 물질

4

반응물 2

HCID 944Nitric AcidHCID 57433539Methyl 2-fluoro-4-[(pyridine-2-carbonyl)amino]benzoate

생성물 1

HCID 57433540HCID 57433540, 화합물

시약·촉매·용매 1

HCID 10340Sodium Carbonate용매

실험 절차

With cooling with ice, fuming nitric acid (110 ml) was gradually added to methyl 2-fluoro-4-[(2-pyridinylcarbonyl)amino]benzoate (27.7 g), and stirred at room temperature for 1.5 hours. With cooling with ice, the reaction liquid was gradually added to an aqueous solution (2000 ml) of sodium carbonate (138 g), and the formed solid was taken out through filtration. After dried under reduced pressure, the entitled compound was obtained as a yellow solid.

후처리

  1. temperatureWith cooling with ice
  2. customthe reaction liquid
  3. filtrationthe formed solid was taken out through filtration
  4. customAfter dried under reduced pressure
  5. customthe entitled compound was obtained as a yellow solid

출처 및 근거

ORD 기록
ord-f19ca06b113e4f64808c7f7153e5b9a6
출처 데이터셋
uspto-grants-2011_08
특허 번호
US07994331B2

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