Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 3-Hydroxy-4-methyl-2-nitrobenzoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | 3-Acetamido-4-methyl-2-nitrobenzoic acid | HCID 243433 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 3-Hydroxy-4-methyl-2-nitrobenzoic acid | HCID 81374 | 93.4% |
반응 단계
A solution of 3-(acetylamino)-4-methyl-2-nitrobenzoic acid (237.5 g, 0.997 mol) and KOH (451.2 g, 8.04 mol) in water (2830 mL) was refluxed for 48 h. The dark red solution was cooled and acidified to pH 1 with concentrated HCl. The yellow solid was filtered and re-crystallized from water (1800 mL) to give the title compound (183 g, 93.4%) as a yellow solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07998978B2 |
| 출처 데이터셋 | uspto-grants-2011_08 |
| ORD ID | ord-38c31f1419744cd699942a50b6d9a0af |
| 출처 메모 | uspto-grants-2011_08 |