Trifluoroacetic acid → HCID 24962060, 화합물

HRID 1672502노트

반응식

HRID 1672502 반응식
C(O)(C(F)(F)F)=O.[Br:8][C:9]1[C:10]([O:22][C:23]2[C:30]([CH3:31])=[CH:29][C:26]([C:27]#[N:28])=[CH:25][C:24]=2[CH3:32])=[N:11][C:12]([NH:15][CH:16]2[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]2)=[N:13][CH:14]=1.Br[CH:34]([C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)[CH3:35]>CC#N>[Br:8][C:9]1[C:10]([O:22][C:23]2[C:30]([CH3:31])=[CH:29][C:26]([C:27]#[N:28])=[CH:25][C:24]=2[CH3:32])=[N:11][C:12]([NH:15][CH:16]2[CH2:17][CH2:18][N:19]([CH:34]([C:36]3[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=3)[CH3:35])[CH2:20][CH2:21]2)=[N:13][CH:14]=1

참가 물질

5

반응물 3

HCID 6422Trifluoroacetic acidHCID 11454(1-Bromoethyl)benzeneHCID 67339367HCID 67339367, 화합물

생성물 1

HCID 24962060HCID 24962060, 화합물

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

To a solution of the TFA salt of 56 (1 mmol) in MeCN was added TEA (1.5 mmol) and (1-bromo-ethyl)-benzene (1 mmol) and the resulting mixture was stirred at RT for 6 h. After the reaction was complete, the solvent was removed and the residue was purified by preparative HPLC on a 30×100 mm C18 ODB column eluting with MeCN/H2O to afford 0.120 g (24.6%) of I-61.

후처리

  1. customthe solvent was removed
  2. customthe residue was purified by preparative HPLC on a 30×100 mm C18 ODB column
  3. washeluting with MeCN/H2O
  4. customto afford 0.120 g (24.6%) of I-61

출처 및 근거

ORD 기록
ord-84042b50f44e4ed6a9abb0908d5b6735
출처 데이터셋
uspto-grants-2011_08
특허 번호
US07998969B2

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