Pyridine → HCID 19170012, 화합물
반응식
[I:1][C:2]1[CH:11]=[CH:10][CH:9]=[CH:8][C:3]=1[C:4]([NH:6][NH2:7])=[O:5].N1C=CC=CC=1.[C:18](Cl)(=[O:20])[CH3:19]>ClCCl>[C:18]([NH:7][NH:6][C:4](=[O:5])[C:3]1[CH:8]=[CH:9][CH:10]=[CH:11][C:2]=1[I:1])(=[O:20])[CH3:19]참가 물질
5
반응 조건
- 온도
- 0 °C
실험 절차
2-Iodobenzohydrazide (1.38 g, 5.27 mmol) obtained in Step 1 of Example 114 was dissolved in dichloromethane (50 mL), and the mixture was stirred at 0° C. for 1.5 hours after adding pyridine (0.639 mL, 7.90 mmol) and acetyl chloride (0.412 mL, 5.79 mmol). The precipitated solid was filtered off, and the resulting solid was dried under reduced pressure to give N′-acetyl-2-iodobenzohydrazide (1.23 g, 77%).
후처리
- filtrationThe precipitated solid was filtered off
- customthe resulting solid was dried under reduced pressure
출처 및 근거
- ORD 기록
- ord-964784db775d4e29a25e91b4cee09636
- 출처 데이터셋
- uspto-grants-2011_08
- 특허 번호
- US07998954B2
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