5-Hydroxymethyl-2-(3-iodophenyl)-1,3-oxazole → 5-Formyl-2-(3-iodophenyl)-1,3-oxazole

HRID 1672826노트

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HRID 1672826 반응식
[OH:1][CH2:2][C:3]1[O:7][C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([I:14])[CH:9]=2)=[N:5][CH:4]=1>ClCCl.[O-2].[O-2].[Mn+4]>[CH:2]([C:3]1[O:7][C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([I:14])[CH:9]=2)=[N:5][CH:4]=1)=[O:1]

참가 물질

4

반응물 1

HCID 673509105-Hydroxymethyl-2-(3-iodophenyl)-1,3-oxazole

생성물 1

HCID 866437045-Formyl-2-(3-iodophenyl)-1,3-oxazole수율 91.4%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6344Dichloromethane용매

실험 절차

5-Hydroxymethyl-2-(3-iodophenyl)-1,3-oxazole (747 mg, 2.48 mmol) obtained in Step 2 of Example 122 was dissolved in dichloromethane (30 mL), and the mixture was stirred at room temperature for 2 hours after adding manganese dioxide (2.16 g, 24.8 mmol). The solid was separated by filtration through sellite. The filtrate was concentrated, and purified by silica gel column chromatography to give 5-formyl-2-(3-iodophenyl)-1,3-oxazole (678 mg, 91%).

후처리

  1. customThe solid was separated by filtration through sellite
  2. concentrationThe filtrate was concentrated
  3. custompurified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-9b082a3444de414e8b89be41790c295a
출처 데이터셋
uspto-grants-2011_08
특허 번호
US07998954B2

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