Tert-butyl 4-(benzo[1,3]dioxol-5-yl)-2-(4-fluorobenzamido)benzoate → 4-(Benzo[1,3]dioxol-5-yl)-2-(4-fluorobenzamido)benzoic acid

HRID 1673438노트

반응식

HRID 1673438 반응식
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[CH:22]=[CH:21][C:13]([C:14]([O:16]C(C)(C)C)=[O:15])=[C:12]([NH:23][C:24](=[O:32])[C:25]4[CH:30]=[CH:29][C:28]([F:31])=[CH:27][CH:26]=4)[CH:11]=3)=[CH:9][C:4]=2[O:3][CH2:2]1>FC(F)(F)C(O)=O>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[CH:22]=[CH:21][C:13]([C:14]([OH:16])=[O:15])=[C:12]([NH:23][C:24](=[O:32])[C:25]4[CH:30]=[CH:29][C:28]([F:31])=[CH:27][CH:26]=4)[CH:11]=3)=[CH:9][C:4]=2[O:3][CH2:2]1

참가 물질

3

반응물 1

HCID 67344518Tert-butyl 4-(benzo[1,3]dioxol-5-yl)-2-(4-fluorobenzamido)benzoate

생성물 1

HCID 578795914-(Benzo[1,3]dioxol-5-yl)-2-(4-fluorobenzamido)benzoic acid

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

10 mL of trifluoroacetic acid was added to the obtained tert-butyl 4-(benzo[1,3]dioxol-5-yl)-2-(4-fluorobenzamido)benzoate and stirred at room temperature for 2 hours. The solvent was evaporated under reduced pressure and diisopropyl ether was added to the obtained residue and a solid substance was separated by filtration to obtain 39 mg of 4-(benzo[1,3]dioxol-5-yl)-2-(4-fluorobenzamido)benzoic acid as white solid.

후처리

  1. customThe solvent was evaporated under reduced pressure and diisopropyl ether
  2. additionwas added to the obtained residue
  3. customa solid substance was separated by filtration

출처 및 근거

ORD 기록
ord-9efd75568c7d4431a475753ac63b0f5a
출처 데이터셋
uspto-grants-2011_08
특허 번호
US07999132B2

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