Methanol → HCID 57879314, 화합물

HRID 1673453노트

반응식

HRID 1673453 반응식
CO.[C:3]([NH:11][C:12]1[CH:20]=[C:19]([CH:21]2[CH2:25][CH2:24][CH:23]=[CH:22]2)[CH:18]=[CH:17][C:13]=1[C:14]([OH:16])=[O:15])(=[O:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>[C].[Pd].C(OCC)(=O)C>[C:3]([NH:11][C:12]1[CH:20]=[C:19]([CH:21]2[CH2:25][CH2:24][CH2:23][CH2:22]2)[CH:18]=[CH:17][C:13]=1[C:14]([OH:16])=[O:15])(=[O:10])[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

참가 물질

5

반응물 2

HCID 887MethanolHCID 57879367HCID 57879367, 화합물

생성물 1

HCID 57879314HCID 57879314, 화합물

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 8857Ethyl Acetate용매

실험 절차

5.0 mg of 5% palladium-carbon was added to a mixed solution of 1.0 mL of methanol and 0.5 mL of ethyl acetate containing 25 mg of 2-(benzamido)-4-(2-cyclopenten-1-yl)benzoic acid and stirred at room temperature under hydrogen atmosphere for 7 hours and then at 40° C. for 8 hours and stirred at 45° C. for 15 hours. Insoluble were removed by filtration and the solvent was evaporated under reduced pressure. Methanol was added to the obtained residue and a solid substance was separated by filtration to obtain 16 mg of 2-(benzamido)-4-cyclopentyl benzoic acid as white solid.

후처리

  1. waitat 40° C. for 8 hours
  2. stirringstirred at 45° C. for 15 hours
  3. customInsoluble were removed by filtration
  4. customthe solvent was evaporated under reduced pressure
  5. additionMethanol was added to the obtained residue
  6. customa solid substance was separated by filtration

출처 및 근거

ORD 기록
ord-78a3628595f74901b71bec602666574a
출처 데이터셋
uspto-grants-2011_08
특허 번호
US07999132B2

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