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Sodium Carbonate → Tert-butyl 2-(benzamido)-4-(4-phenoxyphenyl)benzoate

HRID 1673462
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HRID 1673462 반응식
[O:1]([C:8]1[CH:13]=[CH:12][C:11](B(O)O)=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(=O)([O-])[O-].[Na+].[Na+].[C:23]([NH:31][C:32]1[CH:44]=[C:43](Br)[CH:42]=[CH:41][C:33]=1[C:34]([O:36][C:37]([CH3:40])([CH3:39])[CH3:38])=[O:35])(=[O:30])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>[Pd+2].C1(P(C2CCCCC2)C2C=CC=CC=2)CCCCC1.CN(C)C(=O)C>[C:23]([NH:31][C:32]1[CH:44]=[C:43]([C:11]2[CH:12]=[CH:13][C:8]([O:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)=[CH:9][CH:10]=2)[CH:42]=[CH:41][C:33]=1[C:34]([O:36][C:37]([CH3:39])([CH3:40])[CH3:38])=[O:35])(=[O:30])[C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1
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참가 물질

6

반응물 3

HCID 10340Sodium CarbonateHCID 27343774-Phenoxyphenylboronic acidHCID 67343005Tert-butyl 2-(benzamido)-4-bromobenzoate

생성물 1

HCID 67341966Tert-butyl 2-(benzamido)-4-(4-phenoxyphenyl)benzoate

시약·촉매·용매 2

HCID 86634613dicyclohexylphenylphosphine palladium(II)촉매2회
HCID 31374
Dimethylacetamide
용매

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온도
110 °C

실험 절차

60 mg of 4-phenoxyphenylboronic acid, 49 mg of sodium carbonate and 6 mg of polymer supported di(acetato) dicyclohexylphenylphosphine palladium(II) were added to 2.5 mL of N,N-dimethylacetamide solution containing 70 mg of tert-butyl 2-(benzamido)-4-bromobenzoate, and stirred at: 110° C. for 24 hours. After the reaction mixture was cooled to room temperature, 6 mg of polymer supported di(acetato) dicyclohexylphenylphosphine palladium(II) was added and stirred at 110° C. for 24 hours. After the reaction mixture was cooled to room temperature, insoluble were removed by filtration and ethyl acetate and 10% citric acid aqueous solution were added. The organic layer was separated and dried over anhydrous magnesium sulfate after washed with 10% citric acid aqueous solution and a saturated sodium chloride aqueous solution sequentially, and the solvent was evaporated under reduced pressure. The obtained residue was purified with silica gel column chromatography [Flash Tube 2008 manufactured by Trikonex company, eluent; hexane: ethyl acetate=4:1] to obtain tert-butyl 2-(benzamido)-4-(4-phenoxyphenyl)benzoate.

후처리

  1. temperatureAfter the reaction mixture was cooled to room temperature
  2. additionwas added
  3. stirringstirred at 110° C. for 24 hours
  4. temperatureAfter the reaction mixture was cooled to room temperature
  5. custominsoluble were removed by filtration and ethyl acetate and 10% citric acid aqueous solution
  6. additionwere added
  7. customThe organic layer was separated
  8. dry with materialdried over anhydrous magnesium sulfate
  9. washafter washed with 10% citric acid aqueous solution
  10. customa saturated sodium chloride aqueous solution sequentially, and the solvent was evaporated under reduced pressure
  11. customThe obtained residue was purified with silica gel column chromatography [Flash Tube 2008 manufactured by Trikonex company, eluent; hexane: ethyl acetate=4:1]

출처 및 근거

ORD 기록
ord-a411bd86c0a241468335082f2f11aead
출처 데이터셋
uspto-grants-2011_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07999132B2

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