Tert-butyl 2-(benzamido)-4-(4-hydroxyphenyl)benzoate → 2-(Benzamido)-4-(4-hydroxyphenyl)benzoic acid

HRID 1673469노트

반응식

HRID 1673469 반응식
[C:1]([NH:9][C:10]1[CH:22]=[C:21]([C:23]2[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][CH:24]=2)[CH:20]=[CH:19][C:11]=1[C:12]([O:14]C(C)(C)C)=[O:13])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>FC(F)(F)C(O)=O>[C:1]([NH:9][C:10]1[CH:22]=[C:21]([C:23]2[CH:24]=[CH:25][C:26]([OH:29])=[CH:27][CH:28]=2)[CH:20]=[CH:19][C:11]=1[C:12]([OH:14])=[O:13])(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

3

반응물 1

HCID 67343868Tert-butyl 2-(benzamido)-4-(4-hydroxyphenyl)benzoate

생성물 1

HCID 578794212-(Benzamido)-4-(4-hydroxyphenyl)benzoic acid

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

10 mL of trifluoroacetic acid was added to the obtained tert-butyl 2-(benzamido)-4-(4-hydroxyphenyl)benzoate and stirred at room temperature for 1 hour. The solvent was evaporated under reduced pressure and the obtained residue was purified with reversed-phase silica gel column chromatography [eluent; 55-90% acetonitrile /0.1% trifluoroacetic acid aqueous solution] to obtain 1.9 mg of 2-(benzamido)-4-(4-hydroxyphenyl)benzoic acid as while solid.

후처리

  1. customThe solvent was evaporated under reduced pressure
  2. customthe obtained residue was purified with reversed-phase silica gel column chromatography [eluent; 55-90% acetonitrile /0.1% trifluoroacetic acid aqueous solution]

출처 및 근거

ORD 기록
ord-b70bf6a76eb14a9a80d64e36bc2157d4
출처 데이터셋
uspto-grants-2011_08
특허 번호
US07999132B2

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