tert-butyl 4-phenyl-2-(5-(1H-pyrrol-1-yl)pyridine-3-carboxamido)benzoate → 4-phenyl-2-(5-(1H-pyrrol-1-yl)pyridine-3-carboxamido)benzoic acid

HRID 1673498노트

반응식

HRID 1673498 반응식
[C:1]1([C:7]2[CH:19]=[CH:18][C:10]([C:11]([O:13]C(C)(C)C)=[O:12])=[C:9]([NH:20][C:21]([C:23]3[CH:24]=[N:25][CH:26]=[C:27]([N:29]4[CH:33]=[CH:32][CH:31]=[CH:30]4)[CH:28]=3)=[O:22])[CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>FC(F)(F)C(O)=O>[C:1]1([C:7]2[CH:19]=[CH:18][C:10]([C:11]([OH:13])=[O:12])=[C:9]([NH:20][C:21]([C:23]3[CH:24]=[N:25][CH:26]=[C:27]([N:29]4[CH:33]=[CH:32][CH:31]=[CH:30]4)[CH:28]=3)=[O:22])[CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

3

반응물 1

HCID 67342180tert-butyl 4-phenyl-2-(5-(1H-pyrrol-1-yl)pyridine-3-carboxamido)benzoate

생성물 1

HCID 578794974-phenyl-2-(5-(1H-pyrrol-1-yl)pyridine-3-carboxamido)benzoic acid

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

10 mL of trifluoroacetic acid was added to the obtained tert-butyl 4-phenyl-2-(5-(1H-pyrrol-1-yl)pyridine-3-carboxamido)benzoate and stirred an room temperature for 2 hours. The solvent was evaporated under reduced pressure, ethyl acetate and water were added and pH was adjusted to pH 7.0 with a saturated sodium hydrogen carbonate aqueous solution. The organic layer was separated and the solvent was evaporated under reduced pressure. Diisopropyl ether was added to the obtained residue and a solid substance was separated by filtration to obtain 23 mg of 4-phenyl-2-(5-(1H-pyrrol-1-yl)pyridine-3-carboxamido)benzoic acid as white solid.

후처리

  1. customThe solvent was evaporated under reduced pressure, ethyl acetate and water
  2. additionwere added
  3. customThe organic layer was separated
  4. customthe solvent was evaporated under reduced pressure
  5. additionDiisopropyl ether was added to the obtained residue
  6. customa solid substance was separated by filtration

출처 및 근거

ORD 기록
ord-064a19b31007467db7307ac17675c872
출처 데이터셋
uspto-grants-2011_08
특허 번호
US07999132B2

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