Tert-butyl 2-(2-acetoxybenzamido)-4-phenethylbenzoate → 2-(2-Hydroxybenzamido)-4-phenethylbenzoic acid

HRID 1673530노트

반응식

HRID 1673530 반응식
C([O:4][C:5]1[CH:34]=[CH:33][CH:32]=[CH:31][C:6]=1[C:7]([NH:9][C:10]1[CH:22]=[C:21]([CH2:23][CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH:20]=[CH:19][C:11]=1[C:12]([O:14]C(C)(C)C)=[O:13])=[O:8])(=O)C>FC(F)(F)C(O)=O>[OH:4][C:5]1[CH:34]=[CH:33][CH:32]=[CH:31][C:6]=1[C:7]([NH:9][C:10]1[CH:22]=[C:21]([CH2:23][CH2:24][C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)[CH:20]=[CH:19][C:11]=1[C:12]([OH:14])=[O:13])=[O:8]

참가 물질

3

반응물 1

HCID 67341697Tert-butyl 2-(2-acetoxybenzamido)-4-phenethylbenzoate

생성물 1

HCID 578793222-(2-Hydroxybenzamido)-4-phenethylbenzoic acid

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

10 mL of trifluoroacetic acid was added to the obtained tert-butyl 2-(2-acetoxybenzamido)-4-phenethylbenzoate and stirred at room temperature for 2 hours. The solvent was evaporated under reduced pressure and 0.50 mL of methanol, 0.50 mL of tetrahydrofuran and 10 mg of potassium carbonate were added to the obtained residue sequentially and stirred at room temperature for 3 hours. After insoluble were removed by filtration, 3.0 mL of 10% citric acid aqueous solution was added and a solid; substance was separated, by filtration to obtain 11 mg of 2-(2-hydroxybenzamido)-4-phenethylbenzoic acid as white solid.

후처리

  1. customThe solvent was evaporated under reduced pressure and 0.50 mL of methanol, 0.50 mL of tetrahydrofuran and 10 mg of potassium carbonate
  2. additionwere added to the obtained residue sequentially
  3. stirringstirred at room temperature for 3 hours
  4. customAfter insoluble were removed by filtration, 3.0 mL of 10% citric acid aqueous solution
  5. additionwas added
  6. customsubstance was separated, by filtration

출처 및 근거

ORD 기록
ord-c6074efba396494aa2dde26bd6388a96
출처 데이터셋
uspto-grants-2011_08
특허 번호
US07999132B2

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