Dichloromethane → 4-(9-cyclohexyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-N-piperidin-4-yl-benzamide

반응식

[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][CH:11]([NH:14][C:15]([c:16]2[cH:17][cH:18][c:19]([NH:22][c:23]3[n:24][cH:25][c:26]4[c:27]([n:43]3)[N:28]([CH:37]3[CH2:38][CH2:39][CH2:40][CH2:41][CH2:42]3)[CH2:29][C:30]([F:35])([F:36])[C:31](=[O:34])[N:32]4[CH3:33])[cH:20][cH:21]2)=[O:44])[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[Cl:52][CH2:53][Cl:54].[OH:45][C:46]([C:47]([F:48])([F:49])[F:50])=[O:51]>>[NH:8]1[CH2:9][CH2:10][CH:11]([NH:14][C:15]([c:16]2[cH:17][cH:18][c:19]([NH:22][c:23]3[n:24][cH:25][c:26]4[c:27]([n:43]3)[N:28]([CH:37]3[CH2:38][CH2:39][CH2:40][CH2:41][CH2:42]3)[CH2:29][C:30]([F:35])([F:36])[C:31](=[O:34])[N:32]4[CH3:33])[cH:20][cH:21]2)=[O:44])[CH2:12][CH2:13]1