4,6-Dichloro-2-methylpyrimidine → HCID 85836153, 화합물

반응식

Cl[C:2]1[CH:7]=[C:6](Cl)[N:5]=[C:4]([CH3:9])[N:3]=1.[NH2:10][C:11]1[CH:12]=[C:13]([OH:21])[CH:14]=[C:15]([C:17]([F:20])([F:19])[F:18])[CH:16]=1>>[CH3:9][C:4]1[N:5]=[C:6]([NH:10][C:11]2[CH:16]=[C:15]([C:17]([F:18])([F:19])[F:20])[CH:14]=[C:13]([OH:21])[CH:12]=2)[CH:7]=[C:2]([NH:10][C:11]2[CH:16]=[C:15]([C:17]([F:18])([F:19])[F:20])[CH:14]=[C:13]([OH:21])[CH:12]=2)[N:3]=1

참가 물질

반응물 2

HCID 2349974,6-Dichloro-2-methylpyrimidine

HCID 144012293-Amino-5-(trifluoromethyl)phenol

생성물 1

HCID 85836153HCID 85836153, 화합물수율 43%

실험 절차

This compound was obtained (yield 43%) based on the method described in Production Example 2B using 4,6-dichloro-2-methylpyrimidine instead of the 4,6-dichloro-2-ethylpyrimidine, and using 3-amino-5-trifluoromethyl-phenol instead of the 3-aminophenol.

후처리

customThis compound was obtained (yield 43%)

출처 및 근거

ORD 기록: ord-bb7d696d2c4a4793b040f2030864a376
출처 데이터셋: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08003645B2

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