참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | 4-(6-Benzyloxy-3-cyanoindol-1-yl)-2-methoxymethoxybenzoic acid ethyl ester | HCID 58437286 | — |
| 촉매 | HCID 178418390 | HCID 178418390 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 4-(3-Cyano-6-hydroxyindol-1-yl)-2-methoxymethoxybenzoic acid ethyl ester | HCID 58437526 | — |
반응 단계
To a solution of 4-(6-benzyloxy-3-cyanoindol-1-yl)-2-methoxymethoxybenzoic acid ethyl ester in a mixed solvent of ethyl acetate (60 mL) and methanol (60 mL) was added palladium-carbon powder (0.61 g) under argon atmosphere at 0° C. and this mixture was stirred at 40° C. under a hydrogen atmosphere for 3 hours. The insoluble material was removed by filtration, and the filtrate was concentrated under reduced pressure to give the title compound (2.5 g)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08003647B2 |
|---|
| 출처 데이터셋 | uspto-grants-2011_08 |
|---|
| ORD ID | ord-2fb34ff348da4908b91f6dd56d4e6164 |
|---|
| 출처 메모 | uspto-grants-2011_08 |
|---|
