3,4-Dimethoxybenzenesulfonyl chloride → N-(2-chloro-5-hydroxymethyl-phenyl)-3,4-dimethoxy-benzenesulfonamide

HRID 1674627노트

반응식

HRID 1674627 반응식
[NH2:1][C:2]1[CH:3]=[C:4]([CH2:9][OH:10])[CH:5]=[CH:6][C:7]=1[Cl:8].[CH3:11][O:12][C:13]1[CH:14]=[C:15]([S:21](Cl)(=[O:23])=[O:22])[CH:16]=[CH:17][C:18]=1[O:19][CH3:20]>N1C=CC=CC=1>[Cl:8][C:7]1[CH:6]=[CH:5][C:4]([CH2:9][OH:10])=[CH:3][C:2]=1[NH:1][S:21]([C:15]1[CH:16]=[CH:17][C:18]([O:19][CH3:20])=[C:13]([O:12][CH3:11])[CH:14]=1)(=[O:23])=[O:22]

참가 물질

4

반응물 2

HCID 27341833,4-Dimethoxybenzenesulfonyl chlorideHCID 13636475(3-Amino-4-chlorophenyl)methanol

생성물 1

HCID 57511303N-(2-chloro-5-hydroxymethyl-phenyl)-3,4-dimethoxy-benzenesulfonamide

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

A solution of (3-amino-4-chloro-phenyl)-methanol (2.0 g, 12.7 mmol) in pyridine (26 mL) was treated with 3,4-dimethoxybenzenesulfonyl chloride (3.3 g, 1.1 eq). The solution was stirred at RT overnight. The mixture was then partitioned between EA and 3M HCl. The organic layer was washed with brine, dried over MgSO4 and concentrated. The product was recovered as a brownish foam.

후처리

  1. customThe mixture was then partitioned between EA and 3M HCl
  2. washThe organic layer was washed with brine
  3. dry with materialdried over MgSO4
  4. concentrationconcentrated
  5. customThe product was recovered as a brownish foam

출처 및 근거

ORD 기록
ord-2ca004509b7442898c7610746b030470
출처 데이터셋
uspto-grants-2011_08
특허 번호
US08003654B2

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