5-Bromo-2-chloro-4-(methylthio)pyrimidine → HCID 59550889, 화합물
반응식
[Br:1][C:2]1[C:3]([S:9][CH3:10])=[N:4][C:5](Cl)=[N:6][CH:7]=1.[NH2:11][C:12]1[CH:13]=[C:14]([S:18]([CH3:26])(=[N:20][C:21]([O:23][CH2:24][CH3:25])=[O:22])=[O:19])[CH:15]=[CH:16][CH:17]=1>C(#N)C>[CH2:24]([O:23][C:21]([N:20]=[S:18]([C:14]1[CH:15]=[CH:16][CH:17]=[C:12]([NH:11][C:5]2[N:4]=[C:3]([S:9][CH3:10])[C:2]([Br:1])=[CH:7][N:6]=2)[CH:13]=1)([CH3:26])=[O:19])=[O:22])[CH3:25]참가 물질
4
실험 절차
Intermediate 13 was prepared in analogy to GP 2 by reaction of 2.15 g of Intermediate 12 (4.5 mmol, 1 eq.) and 1.09 g of Intermediate 5 (4.5 mmol, 1 eq.) to yield (after crystallization from acetonitrile) 1.2 g of Intermediate 13 (60% yield).
후처리
- customto yield
출처 및 근거
- ORD 기록
- ord-43df76c199b84c2dbbc348c64b5e97f1
- 출처 데이터셋
- uspto-grants-2011_08
- 특허 번호
- US08003655B2
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