Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
6-Chloro-3-(trifluoromethyl)-(1,2,4)triazolo(4,3-b)pyridazine → 6-[4-(6-Bromonaphthalen-2-yl)sulfonylpiperazin-1-yl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 6-Chloro-3-(trifluoromethyl)-(1,2,4)triazolo(4,3-b)pyridazine | HCID 613657 | — |
| 반응물 | 1-(6-Bromonaphthalene-2-sulfonyl)piperazine | HCID 22329709 | — |
| 생성물 | 6-[4-(6-Bromonaphthalen-2-yl)sulfonylpiperazin-1-yl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine | HCID 67340202 | — |
반응 단계
A mixture of 1-(6-bromonaphthalen-2-yl)sulfonylpiperazine and 6-chloro-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine was allowed to react by General Synthetic Method 3. The crude product was purified by hplc using a Waters XTerra C18 column (5μ silica, 19 mm diameter, 100 mm length) eluted with decreasingly polar mixtures of water (containing 0.1% aqueous ammonia) and acetonitrile as eluents to give 6-[4-(6-bromonaphthalen-2-yl)sulfonylpiperazin-1-yl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08003649B2 |
| 출처 데이터셋 | uspto-grants-2011_08 |
| ORD ID | ord-404c69efdea6413cbe7a0b7ea4034c9c |
| 출처 메모 | uspto-grants-2011_08 |