Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
6-Piperazino-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine → 6-[4-[(6-Morpholin-4-ylpyridin-3-yl)methyl]piperazin-1-yl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 6-Piperazino-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine | HCID 1476862 | — |
| 반응물 | 6-(Morpholin-4-yl)pyridine-3-carbaldehyde | HCID 2776463 | — |
| 생성물 | 6-[4-[(6-Morpholin-4-ylpyridin-3-yl)methyl]piperazin-1-yl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine | HCID 67341015 | — |
반응 단계
Reductive amination of 6-(piperazin-1-yl)-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine with 6-morpholin-4-ylpyridine-3-carbaldehyde was carried out according to General Synthetic Method 7. The crude product was purified by hplc using a Waters XBridge Prep C18 OBD column, 5μ silica, 30 mm diameter, 100 mm length eluted with decreasingly polar mixtures of water (containing 0.1% aqueous ammonia) and acetonitrile as eluents to give 6-[4-[(6-morpholin-4-ylpyridin-3-yl)methyl]piperazin-1-yl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08003649B2 |
| 출처 데이터셋 | uspto-grants-2011_08 |
| ORD ID | ord-c729d875a5db429f808de93ee3c19038 |
| 출처 메모 | uspto-grants-2011_08 |