6-Chloro-3-(trifluoromethyl)-(1,2,4)triazolo(4,3-b)pyridazine → HCID 59149764, 화합물
반응식
[CH3:1][O:2][C:3]1[N:8]=[CH:7][C:6]([C:9]2([OH:15])[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[CH:5][CH:4]=1.Cl[C:17]1[CH:18]=[CH:19][C:20]2[N:21]([C:23]([C:26]([F:29])([F:28])[F:27])=[N:24][N:25]=2)[N:22]=1>>[CH3:1][O:2][C:3]1[N:8]=[CH:7][C:6]([C:9]2([OH:15])[CH2:14][CH2:13][N:12]([C:17]3[CH:18]=[CH:19][C:20]4[N:21]([C:23]([C:26]([F:27])([F:29])[F:28])=[N:24][N:25]=4)[N:22]=3)[CH2:11][CH2:10]2)=[CH:5][CH:4]=1참가 물질
3
실험 절차
A mixture of 4-(6-methoxypyridin-3-yl)piperidin-4-ol and 6-chloro-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine was allowed to react by the method of Example 306 to give 4-(6-methoxypyridin-3-yl)-1-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-ol in 58% yield.
후처리
- customto react by the method of Example 306
출처 및 근거
- ORD 기록
- ord-9e8f7b3f6671439ca70821de36d72397
- 출처 데이터셋