1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-1,4-diazepane → 3-[Chloro(difluoro)methyl]-6-[4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-1,4-diazepan-1-yl][1,2,4]triazolo[4,3-b]pyridazine

HRID 1675038

반응식

HRID 1675038 반응식
[Cl:1][C:2]1[C:3]([N:12]2[CH2:18][CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.Cl[C:20]1[CH:21]=[CH:22][C:23]2[N:24]([C:26]([C:29]([Cl:32])([F:31])[F:30])=[N:27][N:28]=2)[N:25]=1>>[Cl:32][C:29]([F:30])([F:31])[C:26]1[N:24]2[N:25]=[C:20]([N:15]3[CH2:16][CH2:17][CH2:18][N:12]([C:3]4[C:2]([Cl:1])=[CH:7][C:6]([C:8]([F:9])([F:10])[F:11])=[CH:5][N:4]=4)[CH2:13][CH2:14]3)[CH:21]=[CH:22][C:23]2=[N:28][N:27]=1

참가 물질

3

반응물 2

HCID 7357341-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-1,4-diazepaneHCID 14891146-Chloro-3-[chloro(difluoro)methyl][1,2,4]triazolo[4,3-b]pyridazine

생성물 1

HCID 591497183-[Chloro(difluoro)methyl]-6-[4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-1,4-diazepan-1-yl][1,2,4]triazolo[4,3-b]pyridazine수율 62%

실험 절차

A mixture of 1-(3-chloro-5-trifluoromethyl-2-pyridyl)-1,4-diazepane and 6-chloro-3-[chloro(difluoro)methyl]-[1,2,4]triazolo[4,3-b]pyridazine was allowed to react by an analogous method to Example 339 to give 3-[chloro(difluoro)methyl]-6-[4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-1,4-diazepan-1-yl][1,2,4]triazolo[4,3-b]pyridazine in 62% yield.

후처리

  1. customto react by an analogous method to Example 339

출처 및 근거

ORD 기록
ord-d1052e13dd7840928715fd08ddbf8622
출처 데이터셋
uspto-grants-2011_08
특허 번호
US08003649B2

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