benzyl 4-(4-hydroxyphenyl)-5,6-dihydropyridine-1(2H)-carboxylate → 4-Piperidin-4-ylphenol
반응식
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH2:13][CH2:12][N:11](C(OCC3C=CC=CC=3)=O)[CH2:10][CH:9]=2)=[CH:4][CH:3]=1>[Pd].CO>[NH:11]1[CH2:12][CH2:13][CH:8]([C:5]2[CH:4]=[CH:3][C:2]([OH:1])=[CH:7][CH:6]=2)[CH2:9][CH2:10]1참가 물질
4
실험 절차
Benzyl 4-(4-hydroxyphenyl)-5,6-dihydropyridine-1(2H)-carboxylate (37.7 g, 121.86 mmol) and 5% palladium on carbon (7.6 g, 3.57 mmol) in methanol (380 mL) were stirred under an atmosphere of hydrogen at 5 bar and 25° C. for 2 hours. The catalyst was removed by filtration, washed with MeOH and the solvents evaporated. The crude material was triturated with diethyl ether, then the desired product collected by filtration and dried under vacuum to afford 4-(piperidin-4-yl)phenol (20.36 g, 94%) as a solid.
후처리
- customThe catalyst was removed by filtration
- washwashed with MeOH
- customthe solvents evaporated
- customThe crude material was triturated with diethyl ether
- filtrationthe desired product collected by filtration
- customdried under vacuum
출처 및 근거
- ORD 기록
- ord-6c054b9f826644bf82a98a7b90a4a23a
- 출처 데이터셋
- uspto-grants-2011_08
- 특허 번호
- US08003649B2
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