6-Chloro-3-(trifluoromethyl)-(1,2,4)triazolo(4,3-b)pyridazine → 6-[3-(Phenoxymethyl)piperidin-1-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine
반응식
Cl[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([C:11]([F:14])([F:13])[F:12])=[N:9][N:10]=2)[N:7]=1.[O:15]([CH2:22][CH:23]1[CH2:28][CH2:27][CH2:26][NH:25][CH2:24]1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[O:15]([CH2:22][CH:23]1[CH2:28][CH2:27][CH2:26][N:25]([C:2]2[CH:3]=[CH:4][C:5]3[N:6]([C:8]([C:11]([F:14])([F:13])[F:12])=[N:9][N:10]=3)[N:7]=2)[CH2:24]1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1참가 물질
3
실험 절차
Obtained in 60% yield by an analogous method to Example 515, starting from 6-chloro-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine and 3-(phenoxymethyl)piperidine.
후처리
- customObtained in 60% yield by an analogous method to Example 515