Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(2-{4-[3-Methyl-4-(6-methyl-pyridin-3-yloxy)-phenylamino]-quinazolin-6-ylcarbamoyl}-ethyl)-carbamic acid t-butylester → Allitinib metabolite M6
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (2-{4-[3-Methyl-4-(6-methyl-pyridin-3-yloxy)-phenylamino]-quinazolin-6-ylcarbamoyl}-ethyl)-carbamic acid t-butylester | HCID 11699363 | — |
| 반응물 | 3-Amino-N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl)propanamide | HCID 67334123 | — |
| 생성물 | Allitinib metabolite M6 | HCID 53630477 | — |
반응 단계
The procedure of (20-1) of Example 20 was repeated except for using 1 g of the compound obtained in Example 49 instead of the compound obtained in (1-4) of Example 1 to obtain the title compound (0.79 g, 98%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08003658B2 |
| 출처 데이터셋 | uspto-grants-2011_08 |
| ORD ID | ord-9d8f1d311f49461e828beaf4a7b7b461 |
| 출처 메모 | uspto-grants-2011_08 |