Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 2-(Chloromethyl)-5-(4-(trifluoromethyl)phenyl)thiophene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | 2-Thiophenemethanol, 5-[4-(trifluoromethyl)phenyl]- | HCID 21986352 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2-(Chloromethyl)-5-(4-(trifluoromethyl)phenyl)thiophene | HCID 57594979 | — |
반응 단계
To a solution of 61.3 (45 mg, 0.18 mmol) in DCM (0.9 mL) were added triethylamine (24 μL, 0.18 mmol) and thionyl chloride (19 μL, 0.26 mmol) at room temperature. The mixture was stirred overnight and concentrated to afford 61.4. The crude product was used without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08003648B2 |
| 출처 데이터셋 | uspto-grants-2011_08 |
| ORD ID | ord-770aa0a6ed184a3e9e55631ad9668879 |
| 출처 메모 | uspto-grants-2011_08 |