Pyridine → HCID 59300614, 화합물
반응식
[C:1]([O:4][CH2:5][C:6]1[S:7][CH:8]=[CH:9][C:10]=1[CH3:11])(=[O:3])[CH3:2].N1C=CC=CC=1.[Br:18]Br>C(Cl)Cl>[C:1]([O:4][CH2:5][C:6]1[S:7][C:8]([Br:18])=[CH:9][C:10]=1[CH3:11])(=[O:3])[CH3:2]참가 물질
5
반응 조건
- 온도
- 0 °C
실험 절차
To a solution of 62.3 (0.61 g, 3.58 mmol) and pyridine (0.29 mL, 3.58 mmol) in DCM (24 mL) was added bromine (3.58 mL, 1.0 M solution in DCM) dropwise at 0° C. The mixture was stirred for 30 minutes at 0° C. and warmed to room temperature over 1 Hour. Upon completion, the reaction was diluted with DCM, washed with saturated Na2S2O3 and brine, dried (Na2SO4), and concentrated to afford 62.4. The crude product was used without further purification.
후처리
- temperaturewarmed to room temperature over 1 Hour
- washwashed with saturated Na2S2O3 and brine
- dry with materialdried (Na2SO4)
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-8ea5de703b8240f6801bd8d7e0d3bf21
- 출처 데이터셋
- uspto-grants-2011_08
- 특허 번호
- US08003648B2
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