Ammonia → Ethyl 4-isopropylthiazole-2-carboxylate
반응식
Br[CH2:2][C:3](=O)[CH:4]([CH3:6])[CH3:5].C(OC(C1O[S:15]C=CC=1)=O)C.[NH3:19].[CH3:20][CH2:21][O:22][C:23]([CH3:25])=[O:24]>C(O)C.O>[CH:4]([C:3]1[N:19]=[C:25]([C:23]([O:22][CH2:21][CH3:20])=[O:24])[S:15][CH:2]=1)([CH3:6])[CH3:5]참가 물질
7
반응 조건
- 온도
- 0 °C
실험 절차
A solution of compound 35 (3.5 g, 1.25 eq.) and ethylthioxamate (2.3 g, 1 eq.) in ethanol (40 mL) was heated to 80° C. for 6 hrs, and then cooled to 0° C. The reaction mixture was diluted with water and EtOAc, and then neutralized to pH 7 with NH3 (28%). The aqueous layer was extracted with EtOAc. The combined organic layers were dried over sodium sulfate and then removed under reduced pressure. The residue was purified by chromatography on silica gel to yield compound 36 as yellow oil in quantitative yield.
후처리
- extractionThe aqueous layer was extracted with EtOAc
- dry with materialThe combined organic layers were dried over sodium sulfate
- customremoved under reduced pressure
- customThe residue was purified by chromatography on silica gel
출처 및 근거
- ORD 기록
- ord-7e6c602672d04bc89904c29feef08de2
- 출처 데이터셋
- uspto-grants-2011_08
- 특허 번호
- US08003659B2
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